PRAME Antibody, FITC conjugated

$210.00$377.00

Cat. No.: 44078 Categories: ,

Description

Aliases

Opa-interacting protein 4, OIP-4, Preferentially expressed antigen of melanoma, MAPE, OIP4, PRAME

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

P78395

Immunogen

Recombinant human Melanoma antigen preferentially expressed in tumors protein (1-509AA)

Raised In

Rabbit

Species Reactivity

Human

Tested Applications

ELISA;Not yet tested in other applications.

Background / Function

Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.

Isotype

IgG

Conjugate

FITC

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Literature

[1]”Initial characterization of the human central proteome.” Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) . [2]”PRAME is a membrane and cytoplasmic protein aberrantly expressed in chronic lymphocytic leukemia and mantle cell lymphoma.” Proto-Siqueira R., Figueiredo-Pontes L.L., Panepucci R.A., Garcia A.B., Rizzatti E.G., Nascimento F.M., Ishikawa H.C.F., Larson R.E., Falcao R.P., Simpson A.J., Gout I., Filonenko V., Rego E.M., Zago M.A. Leuk. Res. 30:1333-1339(2006). [3]”The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling.” Epping M.T., Wang L., Edel M.J., Carlee L., Hernandez M., Bernards R. Cell 122:835-847(2005).

Additional information

Size

50μg, 100μg

Certificate of Analysis