PRF1 Antibody, FITC conjugated

$210.00$377.00

Cat. No.: 44088 Categories: ,

Description

Aliases

Cytolysin, Lymphocyte pore-forming protein.PRF1, PFP

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

P14222

Immunogen

Recombinant human Perforin-1 protein (22-555AA)

Raised In

Rabbit

Species Reactivity

Human

Tested Applications

ELISA;Not yet tested in other applications.

Background / Function

Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.

Isotype

IgG

Conjugate

FITC

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Research

Immunology

Literature

[1]”Structure and function of human perforin.”Lichtenheld M.G., Olsen K.J., Lu P., Lowrey D.M., Hameed A., Hengartner H., Podack E.R.Nature 335:448-451(1988).

Additional information

Size

50μg, 100μg

Certificate of Analysis