Prnp Antibody

$210.00$377.00

Cat. No.: 44108 Categories: ,

Description

Aliases

Major prion protein, PrP, CD230, Prnp, Prn, Prp

Antibody Type

Polyclonal Antibody

Species

Rat

Uniprot ID

P13852

Immunogen

Recombinant rat Major prion protein (29-231AA)

Raised In

Rabbit

Species Reactivity

Rat

Tested Applications

ELISA;Not yet tested in other applications.

Background / Function

Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.

Isotype

IgG

Conjugate

Unconjugated

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

>95%,Protein G purified

Additional information

Size

50μg, 100μg

Certificate of Analysis