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Propionyl-L-carnitine HCL

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Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids, which has been shown to improve the heart′s mechanical recovery and other metabolic parameters after ischemia-reperfusion.

Cat. No.: 66636 Categories: ,

Description

Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids, which has been shown to improve the heart′s mechanical recovery and other metabolic parameters after ischemia-reperfusion. It stimulates energy production in ischemic muscles by increasing citric acid cycle flux and by stimulating pyruvate dehydrogenase activity and also demonstrates free radical scavenging activity. Propionyl-L-carnitine hydrochloride, also known as PLCAR or Glycine Propionyl-L-Carnitine, is a compound that belongs to the family of carnitine derivatives. Carnitine is an amino acid-like substance that plays a crucial role in energy metabolism and is involved in the transport of fatty acids into the mitochondria, the cellular powerhouses where they are oxidized for energy production.

 

Molecular Formula:C10H20ClNO4

Molecular Weight: 253.72

CAS: 119793-66-7

Assay (%): 98.0 – 102

Product Type: Biochemicals, Building Blocks, Organics, Analytical Reagents

Solubility: Soluble in ethanol (~25 mg/ml), DMSO (~20 mg/ml), DMF (~15 mg/ml), methanol, and water.

Storage: Ambient

References:

  1. Pharmacokinetics of propionyl-L-carnitine in humans: evidence for saturable tubular reabsorption.  |  Pace, S., et al. 2000. Br J Clin Pharmacol. 50: 441-8. PMID: 11069438
  2. Enantio- and chemo-selective HPLC separations by chiral-achiral tandem-columns approach: the combination of CHIROBIOTIC TAG and SCX columns for the analysis of propionyl carnitine and related impurities.  |  D′Acquarica, I., et al. 2004. J Chromatogr A. 1061: 167-73. PMID: 15641359
  3. Propionyl-L-carnitine hydrochloride for treatment of mild to moderate colonic inflammatory bowel diseases.  |  Merra, G., et al. 2012. World J Gastroenterol. 18: 5065-71. PMID: 23049215
  4. Proceedings of the Nineteenth International Society of Sports Nutrition (ISSN) Conference and Expo.  |  VanDusseldorp, T., et al. 2023. J Int Soc Sports Nutr. 20: 2187955. PMID: 37018511

Additional information

Size

100 g, 250 g, 500 g, 1 Kg, BULK

Certificate of Analysis

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