Description
Aliases
Glutaminyl cyclase Glutaminyl-tRNA cyclotransferase Glutamyl cyclase QPCT
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
Q16769
Immunogen
Recombinant human Glutaminyl-peptide cyclotransferase protein (29-361AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
Isotype
IgG
Conjugate
FITC
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Research
Neuroscience
Literature
[1]Molecular cloning, sequence analysis and expression of human pituitary glutaminyl cyclase.Song I., Chuang C.Z., Bateman R.C. Jr.J. Mol. Endocrinol. 13:77-86(1994) [2]Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., SuAdditional information
Size | 50μg, 100μg |
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