Description
Aliases
Receptor-interacting serine/threonine-protein kinase 3 (EC:2.7.11.1), RIPK3, RIP3, RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
Q9Y572
Immunogen
Recombinant human Receptor-interacting serine/threonine-protein kinase 3 protein (1-518AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
Isotype
IgG
Conjugate
FITC
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Additional information
| Size | 50μg, 100μg |
|---|
