Description
Aliases
ACT, Cell growth-inhibiting gene 24/25 protein, Serpin A3, SERPINA3, AACT, GIG24, GIG25
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
P01011
Immunogen
Recombinant human Alpha-1-antichymotrypsin protein (24-423AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA, IHC;Recommended dilution:IHC:1:20-1:200
Background / Function
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antigen Affinity Purified
Literature
[1]Alpha-1-antichymotrypsin gene A1252G variant (ACT Isehara-1) is associated with a lacunar type of ischemic cerebrovascular disease.”Tachikawa H., Tsuda M., Onoe K., Ueno M., Takagi S., Shinohara Y.J. Hum. Genet. 46:45-47(2001). [2]Mis-sense mutation of alpha 1-antichymotrypsin gene associated with chronic lung disease.”Poller W., Faber J.-P., Scholz S., Weindinger S., Bartholome K., Olek K., Eriksson S.Lancet 339:1538-1538(1992). [3]Detection of a new mutant alpha-1-antichymotrypsin in patients with occlusive-cerebrovascular disease.” Tsuda M., Sei Y., Yamamura M., Yamamoto M., Shinohara Y. FEBS Lett. 304:66-68(1992).Additional information
| Size | 50μl, 100μl |
|---|
