Description
Aliases
Hematopoietic proteoglycan core protein, Platelet proteoglycan core protein, Secretory granule proteoglycan core protein, SRGN, PRG, PRG1
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
P10124
Immunogen
Recombinant human Serglycin protein (28-158AA)
Raised In
Rabbit
Species Reactivity
human
Tested Applications
ELISA, IHC;Recommended dilution:IHC:1:20-1:200
Background / Function
Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antigen Affinity Purified
Literature
[1]Serglycin constitutively secreted by myeloma plasma cells is a potent inhibitor of bone mineralization in vitro.”Theocharis A.D., Seidel C., Borset M., Dobra K., Baykov V., Labropoulou V., Kanakis I., Dalas E., Karamanos N.K., Sundan A., Hjerpe A.J. Biol. Chem. 281:35116-35128(2006). [2]Secretion of proteases in serglycin transfected Madin-Darby canine kidney cells.”Zernichow L., Dalen K.T., Prydz K., Winberg J.-O., Kolset S.O.FEBS J. 273:536-547(2006). [3]Localization of serglycin in human neutrophil granulocytes and their precursors.”Niemann C.U., Cowland J.B., Klausen P., Askaa J., Calafat J., Borregaard N.J. Leukoc. Biol. 76:406-415(2004).Additional information
| Size | 50μl, 100μl |
|---|
