STMN1; STN1; stathmin
NCBI Protein: NP_001138926.
Peptide sequence around phosphorylation site of serine 25 (I-L-S(p)-P-R) derived from Human Stathmin 1.
Human Mouse Rat
WB IHC Recommended dilution: Predicted MW: 19kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100,
Background / Function
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear Boehm M, et al. (2002) EMBO J 21(13): 3390-3401.Vadlamudi RK, et al. (2005) Mol Cell Biol 25(9): 3726-3736.Zilfou JT, et al. (2001) Mol Cell Biol 21(12): 3974-3985.Biernat J, et al. (2002) Mol Biol Cell 13(11): 4013-4028.
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.