Mammalian STE20-like protein kinase 3 Mammalian STE20-like protein kinase 3 N-terminal Mammalian STE20-like protein kinase 3 C-terminal STK24 MST3, STK3
Recombinant human Serine/threonine-protein kinase 24 protein (1-431AA)
ELISA, WB, IHC;Not yet tested in other applications.
Background / Function
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on ‘Thr-442’ and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Caprylic Acid Ammonium Sulfate Precipitation purified
LiteratureCloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements.Schinkmann K., Blenis J.J. Biol. Chem. 272:28695-28703(1997) Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 tha