TRPM8 Antibody, Biotin conjugated

Aliases Long transient receptor potential channel 6, LTrpC-6, LTrpC6, Transient receptor potential p8, Trp-p8, LTRPC6, TRPP8, TRPM8 Antibody Type Polyclonal Antibody Species Human Uniprot ID Q7Z2W7 Immunogen Recombinant human Transient receptor potential cation channel subfamily M member 8 protein (1-192AA) Raised In Rabbit Species Reactivity Human Tested Applications ELISA;Not yet tested in other applications. Background / Function Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel. Isotype IgG Conjugate Biotin Storage Buffer Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form Liquid Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze. Purity Caprylic Acid Ammonium Sulfate Precipitation purified Modification Transient receptor potential cation channel subfamily M member 8 Literature [1]”Trafficking and assembly of the cold-sensitive TRPM8 channel.” Erler I., Al-Ansary D.M., Wissenbach U., Wagner T.F., Flockerzi V., Niemeyer B.A. J. Biol. Chem. 281:38396-38404(2006). [2]”The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels.” Voets T., Droogmans G., Wissenbach U., Janssens A., Flockerzi V., Nilius B. Nature 430:748-754(2004). [3]”Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein trp-p8.” Kiessling A., Fuessel S., Schmitz M., Stevanovic S., Meye A., Weigle B., Klenk U., Wirth M.P., Rieber E.P. Prostate 56:270-279(2003).