WWOX (Phospho-Tyr33) Antibody

$454.00

Cat. No.: 38921 Categories: ,

Description

Aliases

FOR; WOX1; Aberrant WW domain-containing oxidoreductase;

Antibody Type

Polyclonal Antibody

Uniprot ID

Swiss-Prot#: Q96KM3;
NCBI Gene#: 51741;

Immunogen

Peptide sequence around phosphorylation site of tyrosine 33 (W-V-Y(p)-Y-A) derived from Human WWOX.

Raised In

Rabbit

Species Reactivity

Human Mouse

Tested Applications

WB IHC Recommended dilution: Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Background / Function

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. Bednarek A.K., Cancer Res. 60:2140-2145(2000).Ried K., Hum. Mol. Genet. 9:1651-1663(2000).Bednarek A.K., Cancer Res. 61:8068-8073(2001).

Conjugate

Unconjugated

Storage Buffer

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form

liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Modification

Phospho-Tyr33

Additional information

Size

100?l

Certificate of Analysis