Description
Aliases
E3 ubiquitin-protein ligase ZNRF3, RING finger protein 203, Zinc/RING finger protein 3, ZNRF3, KIAA1133, RNF203
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
Q9ULT6
Immunogen
Recombinant human E3 ubiquitin-protein ligase ZNRF3 protein (56-219AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA, IF;Not yet tested in other applications.
Background / Function
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
>95%,Protein G purified
Additional information
| Size | 50μg, 100μg |
|---|
