SPTLC2 Antibody

Aliases Long chain base biosynthesis protein 2, LCB 2, Long chain base biosynthesis protein 2a, LCB2a, Serine-palmitoyl-CoA transferase 2, SPT 2, SPTLC2, KIAA0526, LCB2 Antibody Type Polyclonal Antibody Species Human Uniprot ID O15270 Immunogen Recombinant human Serine palmitoyltransferase 2 protein (88-562AA) Raised In Rabbit Species Reactivity Human Tested Applications ELISA, WB, IHC, IF;Recommended dilution:WB:1:500-2000, IHC:1:20-1:200, IF:1:50-1:200 Background / Function Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate. Isotype IgG Conjugate Unconjugated Storage Buffer Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form Liquid Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze. Purity Caprylic Acid Ammonium Sulfate Precipitation purified Modification Serine palmitoyltransferase 2 Literature [1]”Hereditary sensory and autonomic neuropathy type 1 (HSANI) caused by a novel mutation in SPTLC2.” Murphy S.M., Ernst D., Wei Y., Laura M., Liu Y.T., Polke J., Blake J., Winer J., Houlden H., Hornemann T., Reilly M.M. Neurology 80:2106-2111(2012). [2]”Initial characterization of the human central proteome.” Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2010). [3]”Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities.” Han G., Gupta S.D., Gable K., Niranjanakumari S., Moitra P., Eichler F., Brown R.H. Jr., Harmon J.M., Dunn T.M. Proc. Natl. Acad. Sci. U.S.A. 106:8186-8191(2008).