VDAC1 Antibody

Conjugate: Non-conjugated. Product Type: Recombinant Antibody. Clonality: Monoclonal. Form: Liquid. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Clone Number: 3A1. Aliases: Voltage-dependent anion-selective channel protein 1, VDAC-1, hVDAC1, Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL, Porin 31HM, VDAC1, VDAC. Immunogen Species: Human. UniProt ID: P21796. Immunogen: A synthesized peptide derived from human VDAC1. Species Reactivity: Human, Mouse, Rat. Tested Applications: ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200. Background: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). Isotype: Rabbit IgG. Purification Method: Affinity-chromatography. Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Target Names: VDAC1.