Description
Aliases
DNA methyltransferase HsaIIIA, DNMT3A
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
Q9Y6K1
Immunogen
Recombinant human DNA (cytosine-5)-methyltransferase 3A protein (680-902AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity
Isotype
IgG
Conjugate
FITC
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Research
Epigenetics and Nuclear Signaling
Literature
[1]”Cloning, expression and chromosome locations of the human DNMT3 gene family.”Xie S., Wang Z., Okano M., Nogami M., Li Y., He W.-W., Okumura K., Li E.Gene 236:87-95(1999) [2]”A novel Dnmt3a isoform produced from an alternative promoter localizes to euAdditional information
| Size | 50μg, 100μg |
|---|
