53BP1 (Phospho-Ser25) Antibody

$454.00

Cat. No.: 38950 Categories: ,

Description

Aliases

P531; TP53B; TP53BP1; TRP53BP1; Tumor suppressor p53-binding protein 1; p53-binding protein 1

Antibody Type

Polyclonal Antibody

Uniprot ID

Swiss-Prot#:Q12888;
NCBI Gene#:7158

Immunogen

Peptide sequence around phosphorylation site of serine 25 (E-D-S(p)-Q-P) derived from Human 53BP1.

Raised In

Rabbit

Species Reactivity

Human Mouse Rat

Tested Applications

IHC IF Recommended dilution: Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:500

Background / Function

Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.

Conjugate

Unconjugated

Storage Buffer

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form

liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Modification

Phospho-Ser25

Additional information

Size

100μl

Certificate of Analysis