Description
Aliases
Ribonucleoside-diphosphate reductase subunit M1, Ribonucleotide reductase large subunit, RRM1, RR1
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
P23921
Immunogen
Recombinant human Ribonucleoside-diphosphate reductase large subunit protein (1-792AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Isotype
IgG
Conjugate
FITC
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Modification
RRM1
Literature
[1]”Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization.”Fairman J.W., Wijerathna S.R., Ahmad M.F., Xu H., Nakano R., Jha S., Prendergast J., Welin R.M., Flodin S., Roos A., Nordlund P., Li Z., Walz T., Dealwis C.G.Nat. Struct. Mol. Biol. 18:316-322(2010). [2]”Enzyme regulation. IRBIT is a novel regulator of ribonucleotide reductase in higher eukaryotes.”Arnaoutov A., Dasso M.Science 345:1512-1515(2013). [3]”Initial characterization of the human central proteome.” Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2010).Additional information
Size | 50μg, 100μg |
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