ARF6 Antibody, HRP conjugated

$210.00$377.00

Description

Aliases

ARF6, ADP-ribosylation factor 6

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

P62330

Immunogen

Recombinant human ADP-ribosylation factor 6 protein (1-175AA)

Raised In

Rabbit

Species Reactivity

Human

Tested Applications

ELISA;Not yet tested in other applications.

Background / Function

GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.

Isotype

IgG

Conjugate

HRP

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Literature

[1]”The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold.” Selyunin A.S., Sutton S.E., Weigele B.A., Reddick L.E., Orchard R.C., Bresson S.M., Tomchick D.R., Alto N.M. Nature 469:107-111(2011). [2]”The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism.” Ismail S.A., Vetter I.R., Sot B., Wittinghofer A. Cell 141:812-821(2010). [3]”The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4.” Isabet T., Montagnac G., Regazzoni K., Raynal B., El Khadali F., England P., Franco M., Chavrier P., Houdusse A., Menetrey J. EMBO J. 28:2835-2845(2009).

Additional information

Size

50μg, 100μg

Certificate of Analysis