Efnb3 Antibody

$126.00$377.00

Cat. No.: 41333 Categories: ,

Description

Aliases

Efnb3

Antibody Type

Polyclonal Antibody

Species

Mouse

Uniprot ID

O35393

Immunogen

Recombinant mouse Ephrin-B3 protein (28-227AA)

Raised In

Rabbit

Species Reactivity

Mouse

Tested Applications

ELISA, WB;Not yet tested in other applications.

Background / Function

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.

Isotype

IgG

Conjugate

Unconjugated

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Literature

[1]Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. Wollscheid B., Bausch-Fluck D., Henderson C., O’Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009). [2]Complementary expression of transmembrane ephrins and their receptors in the mouse spinal cord: a possible role in constraining the orientation of longitudinally projecting axons. Imondi R., Wideman C., Kaprielian Z. Development 127:1397-1410(2000). [3]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project Team Genome Res. 14:2121-2127(2004).

Additional information

Size

50μg, 100μg, 50μl, 100μl

Certificate of Analysis