NCBI Protein: NP_057253.2
Peptide sequence around phosphorylation site of Serine 342 (A-P-S(p)-R-K) derived from Human Sufu.
WB Recommended dilution: Predicted MW: 54kd, Western blotting: 1:500~1:1000,
Background / Function
SUFU encodes a component of the Sonic hedgehog (SHH; MIM 600725)/Patched (PTCH; MIM 601309) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes (e.g., HPE3, MIM 142945; BCNS, MIM 109400; and GCPS, MIM 175700)Zimmern P,et al.(2010) Neurourol Urodyn.29(5):715-8.Wang C,et al. (2010) Development. 137(12):2001-9. Rabasseda X.et al.(2010) Drug News Perspect.23(4):273-5.
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.