TW-37 is a potent inhibitor of BCL-2, which attenuates BCL-2 activation and inhibits multiple BCL-2 family members including BCL-XL and MCL-1. It binds to the BCL-2 homology domain 3 (BH3) groove of BCL-2, preventing the heterodimerization of proapoptotic proteins such as Bid, Bim, and Bad) with BCL-2 and subsequently allowing them to induce apoptosis.
CAS No.: 877877-35-5
Molecular Formula: C33H35NO6S
Solubility: DMSO >100mM
Storage Temp.: -20°C
Handling: Protect from moisture