Antipain dihydrochloride

General Description

Antipain dihydrochloride is a protease inhibitor, originally produced by actinomycetes. It reversibly inhibit serine/cysteine proteases (cathepsin A, B, and D as well as papain) and some trypsin and trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration of antipain can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells. Antipain acts by forming a hemiacetal adduct between the aldehyde group of the inhibitor and the active serine of the proteinase. Effective at concentrations range from 1 to 100 μM.

Molecular Formula:      C₂₇H₄₄N₁₀O₆.2HCl

Molecular weight:         677.62

CAS Number:                 37682-72-7

Appearance:                   White to off-white solid

Solubility:                        Water (> 50 mg/ml) or DMSO (5 mg/ml)

Purity:                              ≥97% by HPLC

Storage:                           Store at -20 ℃. Protect from light and moisture