Antipain, Dihydrochloride, produced by actinomycetes, is a reversible inhibitor of serine/cysteine proteases (cathepsin A, B, and D as well as papain) and some trypsin and trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration of antipain can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells. Antipain acts by forming a hemiacetal adduct between the aldehyde group of the inhibitor and the active serine of the proteinase. Effective at concentrations range from 1 to 100 μM.
Molecular Formula: C27H44N10O6.2HCl
Molecular weight: 677.62
CAS Number: 37682-72-7
Appearance: White to off-white solid
Solubility: Water (> 50 mg/ml) or DMSO (5 mg/ml)
Purity: ≥97% by HPLC
Storage: Store at -20 ℃. Protect from light and moisture