B-ATF-3, Jun dimerization protein 1, JDP-1, Jdp1, Batf3
Recombinant rat Basic leucine zipper transcriptional factor ATF-like 3 protein (1-133AA)
ELISA;Not yet tested in other applications.
Background / Function
AP-1 family transcription factor that controls the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5′-TGA[CG]TCA-3′ and regulates expression of target genes. Required for development of CD8-alpha+ classical dendritic cells (cDCs) and related CD103+ dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity).
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Caprylic Acid Ammonium Sulfate Precipitation purified
Basic leucine zipper transcriptional factor ATF-like 3
Literature”Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions.” Aronheim A., Zandi E., Hennemann H., Elledge S.J., Karin M. Mol. Cell. Biol. 17:3094-3102(1997).