CTNNB1, CTNNB, OK/SW-cl.35, PRO2286, Beta-catenin
Recombinant human Catenin beta-1 protein (2-781AA)
ELISA;Not yet tested in other applications.
Background / Function
Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. Involved in signal transduction through the Wnt pathway. Nuclear beta-catenin it involved in transcriptional regulation by association with transcription factors of the TCF/LEF family.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Caprylic Acid Ammonium Sulfate Precipitation purified
Catenin beta-1 protein
Literature”E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.” Huelsken J., Birchmeier W., Behrens J.J. Cell Biol. 127:2061-2069(1994)