Description
Aliases
DNA methyltransferase HsaIIIA, DNMT3A
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
Q9Y6K1
Immunogen
Recombinant human DNA (cytosine-5)-methyltransferase 3A protein (680-902AA)
Raised In
Rabbit
Species Reactivity
Human,Mouse
Tested Applications
ELISA, IHC;Recommended dilution:IHC:1:20-1:200
Background / Function
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Research
Epigenetics and Nuclear Signaling
Additional information
| Size | 50μg, 100μg |
|---|
