FGFR1/2 (Phospho-Tyr463/466) Antibody

$514.50

Cat. No.: 38581 Categories: ,

Description

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. Itoh N., Biochem. Biophys. Res. Commun. 169:680-685(1990).Dionne C.A., EMBO J. 9:2685-2692(1990).Johnson D.E., Mol. Cell. Biol. 10:4728-4736(1990).

 

Full Product Name

Rabbit anti-Homo sapiens (Human) FGFR1/FGFR2 Polyclonal antibody

 

Clonality

Polyclonal

 

Uniprot ID

P11362

 

Immunogen

Peptide sequence around phosphorylation site of tyrosine 463/466(S-E-Y(p)-E-L) derived from Human FGFR1/2.

 

Raised In

Rabbit

 

Target Names

FGFR1/FGFR2

 

Alternative Names

Basic fibroblast growth factor receptor 1 antibody; bFGF-R-1 antibody; BFGFR antibody; CD331 antibody; CEK antibody; FGFBR antibody; FGFR 1 antibody; FGFR-1 antibody; FGFR1 antibody; FGFR1/PLAG1 fusion antibody; FGFR1_HUMAN antibody; fibroblast growth factor receptor 1 antibody; FLG antibody; FLT-2 antibody; FLT2 antibody; Fms-like gene antibody; Fms-like tyrosine kinase 2 antibody; fms-related tyrosine kinase 2 antibody; HBGFR antibody; heparin-binding growth factor receptor antibody; HH2 antibody; HRTFDS antibody; hydroxyaryl-protein kinase antibody; KAL2 antibody; N-SAM antibody; OGD antibody; Proto-oncogene c-Fgr antibody

 

Purification Method

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

 

Immunogen Species

Homo sapiens (Human)

 

Species Reactivity

Human Mouse

 

Tested Applications

ELISA, WB

 

Conjugate

Unconjugated

 

Storage Buffer

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

 

Form

liquid

 

Concentration

Varies from lot to lot

 

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze and thaw.

 

Modification

Phospho-Tyr463/466

 

Additional information

Size

100 μl

Certificate of Analysis