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GATM Antibody

$112.45$221.55

L-arginine:glycine amidinotransferase, Transamidinase, GATM, AGAT Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine.

Cat. No.: 58173 Categories: ,

Description

Aliases

L-arginine:glycine amidinotransferase, Transamidinase, GATM, AGAT

 

Antibody Type

Polyclonal Antibody

 

Species

Human

 

Uniprot ID

P50440

 

Immunogen

Recombinant human Glycine amidinotransferase, mitochondrial protein (124-423AA)

 

Raised In

Rabbit

 

Species Reactivity

Human,Mouse

 

Tested Applications

ELISA, WB, IHC;Recommended dilution:WB:1:500-5000, IHC:1:20-1:200

 

Background / Function

Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis.

 

Isotype

IgG

 

Conjugate

Unconjugated

 

Storage Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

 

Form

Liquid

 

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

 

Purity

Antigen Affinity Purified

 

Literature

[1]”Creatine deficiency syndrome. A treatable myopathy due to arginine-glycine amidinotransferase (AGAT) deficiency.”Nouioua S., Cheillan D., Zaouidi S., Salomons G.S., Amedjout N., Kessaci F., Boulahdour N., Hamadouche T., Tazir M.Neuromuscul. Disord. 23:670-674(2013). [2]”Biochemical, molecular, and clinical diagnoses of patients with cerebral creatine deficiency syndromes.”Comeaux M.S., Wang J., Wang G., Kleppe S., Zhang V.W., Schmitt E.S., Craigen W.J., Renaud D., Sun Q., Wong L.J.Mol. Genet. Metab. 109:260-268(2013). [3]”Arginine:glycine amidinotransferase deficiency: the third inborn error of creatine metabolism in humans.”Item C.B., Stockler-Ipsiroglu S., Stromberger C., Muhl A., Alessandri M.G., Bianchi M.C., Tosetti M., Fornai F., Cioni G.Am. J. Hum. Genet. 69:1127-1133(2001).

 

Additional information

Size

50μl, 100μl

Certificate of Analysis