p130 Cas (Phospho-Tyr410) Antibody

$454.00

Cat. No.: 38889 Categories: ,

Description

Aliases

BCAR1; CRKAS; CRK-ASSOCIATED SUBSTRATE;

Antibody Type

Polyclonal Antibody

Uniprot ID

Swiss-Prot#: P56945;
NCBI Gene#: 9564;
N

Immunogen

Peptide sequence around phosphorylation site of tyrosine 410(G-V-Y(p)-A-V) derived from Human p130 Cas .

Raised In

Rabbit

Species Reactivity

Human Mouse Rat

Tested Applications

WB IHC Recommended dilution: Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Background / Function

Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.Katarzyna Modzelewska, J. Biol. Chem., Dec 2006; 281: 37527 – 37535.Kevin Ogden, Am J Physiol Heart Circ Physiol, Dec 2006; 291: H2857 – H2863.Sangkil Nam, Cancer Res., Oct 2005; 65: 9185 – 9189.Norikazu Yamana, Mol. Cell. Biol., Sep 2006; 26: 6844 – 6

Conjugate

Unconjugated

Storage Buffer

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form

liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Modification

Phospho-Tyr410

Additional information

Size

100?l

Certificate of Analysis