RRM1 Antibody, HRP conjugated

$210.00$377.00

Description

Aliases

Ribonucleoside-diphosphate reductase subunit M1, Ribonucleotide reductase large subunit, RRM1, RR1

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

P23921

Immunogen

Recombinant human Ribonucleoside-diphosphate reductase large subunit protein (1-792AA)

Raised In

Rabbit

Species Reactivity

Human

Tested Applications

ELISA;Not yet tested in other applications.

Background / Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Isotype

IgG

Conjugate

HRP

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Modification

RRM1

Literature

[1]”Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization.”Fairman J.W., Wijerathna S.R., Ahmad M.F., Xu H., Nakano R., Jha S., Prendergast J., Welin R.M., Flodin S., Roos A., Nordlund P., Li Z., Walz T., Dealwis C.G.Nat. Struct. Mol. Biol. 18:316-322(2010). [2]”Enzyme regulation. IRBIT is a novel regulator of ribonucleotide reductase in higher eukaryotes.”Arnaoutov A., Dasso M.Science 345:1512-1515(2013). [3]”Initial characterization of the human central proteome.” Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2010).

Additional information

Size

50μg, 100μg

Certificate of Analysis