SENP8 Antibody, Biotin conjugated

$210.00$377.00

Cat. No.: 53125 Categories: ,

Description

Aliases

Deneddylase-1, NEDD8-specific protease 1, Protease, cysteine 2, Sentrin/SUMO-specific protease SENP8, SENP8, DEN1, NEDP1, PRSC2, FKSG8

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

Q96LD8

Immunogen

Recombinant human Sentrin-specific protease 8 protein (1-212AA)

Raised In

Rabbit

Species Reactivity

Human

Tested Applications

ELISA;Not yet tested in other applications.

Background / Function

Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.

Isotype

IgG

Conjugate

Biotin

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Literature

[1]”Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1.” Reverter D., Wu K., Erdene T.G., Pan Z.-Q., Wilkinson K.D., Lima C.D. J. Mol. Biol. 345:141-151(2005). [2]”Structural basis of NEDD8 ubiquitin discrimination by the deneddylating enzyme NEDP1.” Shen L.-N., Liu H., Dong C., Xirodimas D.P., Naismith J.H., Hay R.T. EMBO J. 24:1341-1351(2005). [3]”Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.” Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C. Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).

Additional information

Size

50μg, 100μg

Certificate of Analysis