MAS1 Antibody, HRP conjugated

Aliases Proto-oncogene Mas, MAS1, MAS Antibody Type Polyclonal Antibody Species Human Uniprot ID P04201 Immunogen Recombinant human Proto-oncogene Mas protein (285-352AA) Raised In Rabbit Species Reactivity Human Tested Applications ELISA;Not yet tested in other applications. Background / Function Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. Isotype IgG Conjugate HRP Storage Buffer Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form Liquid Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze. Purity Caprylic Acid Ammonium Sulfate Precipitation purified Literature [1]”Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS.”Canals M., Jenkins L., Kellett E., Milligan G.J. Biol. Chem. 281:16757-16767(2006). [2]”G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor.”Kostenis E., Milligan G., Christopoulos A., Sanchez-Ferrer C.F., Heringer-Walther S., Sexton P.M., Gembardt F., Kellett E., Martini L., Vanderheyden P., Schultheiss H.P., Walther T.Circulation 111:1806-1813(2005). [3]”The mas oncogene encodes an angiotensin receptor.”Jackson T.R., Blair L.A.C., Marshall J., Goedert M., Hanley M.R.Nature 335:437-440(1988).