IL1R1 Antibody

Aliases IL-1R-1, IL-1RT-1, IL-1RT1, CD121 antigen-like family member A, Interleukin-1 receptor alpha, IL-1R-alpha, Interleukin-1 receptor type I, p80, IL1R1, IL1R, IL1RA, IL1RT1 Antibody Type Polyclonal Antibody Species Human Uniprot ID P14778 Immunogen Recombinant human Interleukin-1 receptor type 1 protein (18-320AA) Raised In Rabbit Species Reactivity Human,Mouse Tested Applications ELISA, WB, IHC;Recommended dilution:WB:1:500-2000, IHC:1:20-1:200 Background / Function Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Isotype IgG Conjugate Unconjugated Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form Liquid Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze. Purity Antigen Affinity Purified Literature [1]”X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1.”Vigers G.P.A., Dripps D.J., Edwards C.K. III, Brandhuber B.J.J. Biol. Chem. 275:36927-36933(2000). [2]”A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist.”Schreuder H., Tardif C., Trump-Kallmeyer S., Soffientini A., Sarubbi E., Akeson A., Bowlin T., Yanofsky S., Barrett R.W.Nature 386:194-200(1997). [3]”Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta.” Vigers G.P.A., Anderson L.J., Caffes P., Brandhuber B.J.Nature 386:190-194(1997).