ADA Antibody

$210.00$377.00

Cat. No.: 39679 Categories: ,

Description

Aliases

Adenosine deaminase, Adenosine aminohydrolase, ADA, ADA1

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

P00813

Immunogen

Recombinant human Adenosine deaminase protein (157-343AA)

Raised In

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC;Recommended dilution:WB:1:500-2000, IHC:1:20-1:200

Background / Function

Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion.

Isotype

IgG

Conjugate

Unconjugated

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Literature

[1]”The DNA sequence and comparative analysis of human chromosome 20.” Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. Rogers J.Nature 414:865-871(2001). [2]”Molecular characterization of dipeptidyl peptidase activity in serum: soluble CD26/dipeptidyl peptidase IV is responsible for the release of X-Pro dipeptides.” Durinx C., Lambeir A.M., Bosmans E., Falmagne J.B., Berghmans R., Haemers A., Scharpe S., De Meester I.Eur. J. Biochem. 267:5608-5613(2000) [PubMed] [Europe PMC] [Abstract]Cited for: INTERACTION WITH DPP4. [3]”Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interaction.”Gines S., Marino M., Mallol J., Canela E.I., Morimoto C., Callebaut C., Hovanessian A., Casado V., Lluis C., Franco R.Biochem. J. 361:203-209(2002).

Additional information

Size

50μg, 100μg

Certificate of Analysis