Carbenicillin disodium



General Description

Carbenicillin is a broad-spectrum antibiotic, which inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane. It is semi-synthetic penicillin antibiotic with bactericidal and beta-lactamase resistant activity. It acylates the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation prevents the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell wall synthesis. This leads to incomplete bacterial cell wall synthesis and eventually causes cell lysis.


Synonyms:                     Carbenicillin sodium, Carbecin, Sodium carbenicillin, Carbenicillin, Carboxybenzyl Penicillin, Disodium Carbenicillin, Geopen, Microcillin, Pyopen, Carbapen

CAS Number:                4800-94-6;

Molecular Formula:     C17H16N2Na2O6S

Molecular Weight:       422.363



1.  Used for selection of ampr transformed cells.

2. Used to study the role of penicillin-sensitive transpeptidases in cell wall biosynthesis.

3.   Antimicrobial spectrum: Gram-positive and Gram-negative bacteria, Pseudomonas.


Additional information


1 g, 5 g, 25 g, 50 g

Certificate of Analysis