Caspase 6, Human Recombinant
Caspase-6 (also known as Mch2) is a member of the caspase-family of cysteine proteases. Similar to other caspases, Caspase-6 also exists in cells as an inactive proenzyme. During apoptosis procaspase-6 is processed at aspartate residues by self-proteolysis and/or cleavage by another caspase. The processed active form of Caspase-6 consists of large (18 kDa) and small (11 kDa) subunits which associate to form the active enzyme. Active Caspase-6 has been shown to be of importance in the proteolysis of PARP (poly ADP-ribose polymerase), an enzyme that is involved in DNA repair and genomic maintenance. The recombinant active human Caspase-6 was expressed in E. coli.
Synonyms: Caspase-6, CASP-6, Apoptotic protease Mch-2
Gene Symbol: CASP6
Gene ID: 839
Source: E. coli.
Form: Lyophilized powder
Molecular Weight: Large (18 kDa) and small (11 kDa)
Reconstitution Inst: Reconstitute to 1 unit per µl in PBS containing 15% glycerol
Handling: Centrifuge the vial prior to opening
Storage temp.: -70°C