Caspase-8 Inhibitor (Z-IETD-FMK) [1mM]

Description

Caspase Inhibitors, Caspase 8 Inhibitor, fluoromethyl ketone, FMK

General description

It is a synthetic peptide that irreversibly inhibits FLICE and related protease/Caspase-8, granzyme B activity, and blocks apoptosis. IETD is the specific recognition sequence found in CPP32 proenzyme. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups.)

Synonyms:                        Z-IETD-FMK, Z-IETD-fluoromethylketone, Caspase-8 Inhibitor (fluoromethylketone)

Peptide Sequence:          Z-Ile-Glu (OMe)-Thr-Asp (OMe)-FMK

Appearance:                     Lyophilized solid

Molecular Formula:         C₃₀H₄₃FN₄O₁₁

Molecular Weight:           654.7

Solubility:                          DMSO (20 mM)

InChi Key:                         PHLCQASLWHYEMX-UHFFFAOYSA-N

PubChem CID:                 44135212

Handling:                          Protect from light and moisture

Storage temp.:                 -20°C

Additional information