Gab1(Phospho-Tyr627) Antibody

$454.00

Cat. No.: 38826 Categories: ,

Description

Aliases

Growth factor receptor bound protein 2-associated protein 1

Antibody Type

Polyclonal Antibody

Uniprot ID

Swiss-Prot: Q13480
NCBI Protein: NP_002030.2

Immunogen

Peptide sequence around phosphorylation site of tyrosine 627 (V-E-Y(p)-L-D) derived from Human Gab1.

Raised In

Rabbit

Species Reactivity

Human Mouse

Tested Applications

WB IF Recommended dilution: Predicted MW: 110kd, Western blotting: 1:500~1:1000, Immunofluorescence: 1:100~1:200

Background / Function

The protein encoded by Gab1 is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.Anders Kallin, et al. (2004) J. Biol. Chem ; 279: 17897 – 17904.Hideto Kameda, et al. (2001) Cell Growth Differ ; 12: 307. Masaki Osawa, et al. (2002) J. Cell Biol ; 158: 773.

Conjugate

Unconjugated

Storage Buffer

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form

liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Modification

Phospho-Tyr627

Additional information

Size

100?l

Certificate of Analysis