Syn-1; synapsin I;
NCBI Protein: NP_038708.3
Peptide sequence around phosphorylation site of serine 549(P-A-S(p)-P-S)derived from Rat Synapsin
Human Rat Mouse
WB Recommended dilution: Predicted MW: 78kd, Western blotting: 1:500~1:1000
Background / Function
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level Greengard, P. (1987) Mol Neurobiol 1, 81-119. Hosaka, M. et al. (1999) Neuron 24, 377-87.
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.