CD200R1 Antibody

Aliases CD200 cell surface glycoprotein receptor, Cell surface glycoprotein OX2 receptor 1, CD200R1, CD200R, CRTR2, MOX2R, OX2R Antibody Type Polyclonal Antibody Species Human Uniprot ID Q8TD46 Immunogen Recombinant human Cell surface glycoprotein CD200 receptor 1 protein (226-325AA) Raised In Rabbit Species Reactivity Human,Mouse Tested Applications ELISA, WB, IHC;Recommended dilution:WB:1:200-1000, IHC:1:20-1:200 Background / Function Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. Isotype IgG Conjugate Unconjugated Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form Liquid Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze. Purity Antigen Affinity Purified Literature [1]”K14, the HHV-8 viral OX2 homolog interacts with the human OX2 receptor with identical affinity and kinetics as the host OX2 protein.”Wright G.J., Brown M.H., Barclay N.Submitted (JUN-2000). [2]”The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.” Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003). [3]”Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004).