a-catenin(Phospho-Ser641) Antibody

$454.00

Cat. No.: 38838 Categories: ,

Description

Aliases

Cadherin-associated protein; Alpha E-catenin; NY-REN-13 antigen

Antibody Type

Polyclonal Antibody

Uniprot ID

Swiss-Prot: P35221
NCBI Protein: NP_001894.2

Immunogen

Peptide sequence around phosphorylation site of serine 641 (D-D-S(p)-D-F) derived from Human a-catenin.

Raised In

Rabbit

Species Reactivity

Human Mouse

Tested Applications

WB Recommended dilution: Predicted MW: 100kd, Western blotting: 1:500~1:1000

Background / Function

Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. May play a crucial role in cell differentiation. Hwang, S.G. et al. (2005) J. Biol. Chem. 280, 12758-12765 Drees, F. et al. (2005) Cell 123, 903-915. Yamada, S. et al. (2005) Cell 123, 889-901. Kobielak, A. and Fuchs, E. (2004) Nat. Rev. Mol. Cell Biol. 5, 614-625.

Conjugate

Unconjugated

Storage Buffer

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form

liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Modification

Phospho-Ser641

Additional information

Size

100?l

Certificate of Analysis