Description
Aliases
BCL2-like protein 11; BCL2L11; BOD; Bcl-2 related ovarian death protein;
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: O43521
NCBI Protein: NP_006529.1
Immunogen
Peptide sequence around phosphorylation site of serine 69 (P-A-S(p)-P-G) derived from Human BIM.
Raised In
Rabbit
Species Reactivity
Human Mouse Rat
Tested Applications
IHC IF Recommended dilution: Predicted MW: 23kd, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Background / Function
Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-a1, isoform Bim-a2 and isoform Bim-a3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosisFukazawa H, et al. (2004) Mol Cancer Ther ; 3(10): 1281-1288Luciano F, et al. (2003) Oncogene ; 22(43): 6785-6793
Conjugate
Unconjugated
Storage Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Modification
Phospho-Ser69
Additional information
| Size | 100?l |
|---|
