BIM(Phospho-Ser69) Antibody

$454.00

Cat. No.: 38825 Categories: ,

Description

Aliases

BCL2-like protein 11; BCL2L11; BOD; Bcl-2 related ovarian death protein;

Antibody Type

Polyclonal Antibody

Uniprot ID

Swiss-Prot: O43521
NCBI Protein: NP_006529.1

Immunogen

Peptide sequence around phosphorylation site of serine 69 (P-A-S(p)-P-G) derived from Human BIM.

Raised In

Rabbit

Species Reactivity

Human Mouse Rat

Tested Applications

IHC IF Recommended dilution: Predicted MW: 23kd, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

Background / Function

Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-a1, isoform Bim-a2 and isoform Bim-a3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosisFukazawa H, et al. (2004) Mol Cancer Ther ; 3(10): 1281-1288Luciano F, et al. (2003) Oncogene ; 22(43): 6785-6793

Conjugate

Unconjugated

Storage Buffer

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form

liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Modification

Phospho-Ser69

Additional information

Size

100?l

Certificate of Analysis