Description
Aliases
Bcl-2-like protein 1
Antibody Type
Polyclonal Antibody
Uniprot ID
Q07817
Immunogen
Fusion protein of human BCL2L1
Raised In
Rabbit
Species Reactivity
Human, Mouse, Rat
Tested Applications
ELISA: 1:2000-1:5000; WB:1:500-1:2000
Background / Function
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antigen affinity purification
Additional information
| Size | 50μl, 100μl |
|---|
