SHP-1(Phospho-Tyr536) Antibody

$454.00

Cat. No.: 38833 Categories: ,

Description

Aliases

70Z-SHP; HCP; HCPH; Hematopoietic cell protein-tyrosine phosphatase; PTN6

Antibody Type

Polyclonal Antibody

Uniprot ID

Swiss-Prot: P29350
NCBI Protein: NP_002822.2

Immunogen

Peptide sequence around phosphorylation site of tyrosine 536 (S-E-Y(p)-G-N) derived from Human SHP-1.

Raised In

Rabbit

Species Reactivity

Human Mouse Rat

Tested Applications

IHC IF Recommended dilution: Predicted MW: 68kd, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

Background / Function

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.Migone TS, et al. (1998) Proc Natl Acad Sci USA; 95(7): 3845-3850.Timms JF, et al.(1998) Mol Cell Biol; 18(7): 3838-3850.Kanagasundaram V, et al. (1999) Mol Cell Biol; 19(6): 4079-4092.Hauck CR, et al. (1999) Infect Immun; 67(10): 5490-5494.

Conjugate

Unconjugated

Storage Buffer

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form

liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Modification

Phospho-Tyr536

Additional information

Size

100μl

Certificate of Analysis