Description
Aliases
70Z-SHP; HCP; HCPH; Hematopoietic cell protein-tyrosine phosphatase; PTN6
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: P29350
NCBI Protein: NP_002822.2
Immunogen
Peptide sequence around phosphorylation site of tyrosine 536 (S-E-Y(p)-G-N) derived from Human SHP-1.
Raised In
Rabbit
Species Reactivity
Human Mouse Rat
Tested Applications
IHC IF Recommended dilution: Predicted MW: 68kd, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Background / Function
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.Migone TS, et al. (1998) Proc Natl Acad Sci USA; 95(7): 3845-3850.Timms JF, et al.(1998) Mol Cell Biol; 18(7): 3838-3850.Kanagasundaram V, et al. (1999) Mol Cell Biol; 19(6): 4079-4092.Hauck CR, et al. (1999) Infect Immun; 67(10): 5490-5494.
Conjugate
Unconjugated
Storage Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Modification
Phospho-Tyr536
Additional information
| Size | 100μl |
|---|
