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Sulfo EMCS ([N-(E-maleimidocaproyloxy)-sulfo succinimide ester)
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Sulfo SMPB (Sulfo succinimidyl 4-(p-maleimidophenyl)Butyrate)
Sulfo SMPB (Sulfo succinimidyl 4-(p-maleimidophenyl)Butyrate) $303.30

Sulfo EMCS

$311.40 – $523.69

Size

50 mg, 100 mg

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SKU: 10564 Categories: Protein Labeling, Proteomics
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  • Description
  • Manual
  • Safety Datasheet
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Description

Sulfo EMCS ([N-(E-maleimidocaproyloxy)-sulfo succinimide ester), a water-soluble analog of EMCS is a heterobifunctional cross-linker, containing N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl- containing molecules. NHS esters react with primary amines at pH 7-9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5-7.5 to form stable thioether bonds. In aqueous solutions, hydrolytic degradation of the NHS ester is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group but will slowly hydrolyze and also lose its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugation experiments involving these cross-linkers are usually performed at a pH range of 7.2-7.5, with the NHS-ester (amine-targeted) reaction being accomplished before or simultaneously with the maleimide (sulfhydryl-targeted) reaction.

 

Features and Benefits

  • Reactive groups: sulfo-NHS ester and maleimide
  • Reactive towards: amino and sulfhydryl groups
  • Sulfo-NHS ester end couples with primary amines at pH 7-9 to form stable amide bonds
  • Maleimide reacts with -SH groups at pH 6.5-7.5, forming stable thioether linkages
  • Non-cleavable
  • Water-soluble (compare to EMCS)
  • Aliphatic spacer offers low potential for eliciting an immune response
Manual
Download Manual
Safety Datasheet
Download Safety Datasheet
Manual
Certificate of Analysis
Download Certificate of Analysis
Safety Datasheet

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Certificate of Analysis

Certificate of Analysis

Shipping & Delivery
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MAECENAS IACULIS

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ADIPISCING CONVALLIS BULUM

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  • Abitur parturient praesent lectus quam a natoque adipiscing a vestibulum hendre.
  • Diam parturient dictumst parturient scelerisque nibh lectus.

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