IFIT3 Antibody

Aliases IFIT-3, CIG49, ISG-60, Interferon-induced 60 kDa protein, IFI-60K, Interferon-induced protein with tetratricopeptide repeats 4, IFIT-4, Retinoic acid-induced gene G protein, P60, RIG-G Antibody Type Polyclonal Antibody Species Human Uniprot ID O14879 Immunogen Recombinant human Interferon-induced protein with tetratricopeptide repeats 3 protein (1-490AA) Raised In Rabbit Species Reactivity human Tested Applications ELISA, WB, IHC;Recommended dilution:WB:1:500-2000, IHC:1:20-1:200 Background / Function IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. Isotype IgG Conjugate Unconjugated Storage Buffer Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form Liquid Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze. Purity Caprylic Acid Ammonium Sulfate Precipitation purified Research Immunology Literature [1]”IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1.” Liu X.Y., Chen W., Wei B., Shan Y.F., Wang C. J. Immunol. 187:2559-2568(2011). [2]”The interferon stimulated gene 54 promotes apoptosis.”Stawowczyk M., Van Sc