APP(Phospho-Thr668) Antibody

$476.70

Cat. No.: 38794 Categories: ,

Description

Aliases

AAA; AD1; PN2; ABPP; APPI

Antibody Type

Polyclonal Antibody

Uniprot ID

Swiss-Prot: P05067
NCBI Protein: NP_000475.1

Immunogen

Peptide sequence around phosphorylation site of threonine 668 (A-V-T(p)-P-E) derived from Human APP.

Raised In

Rabbit

Species Reactivity

Human Mouse Rat

Tested Applications

WB Recommended dilution: Predicted MW: 100-140 kd, Western blotting: 1:500~1:1000

Background / Function

APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. Hung, A.Y. and Selkoe, D.J. (1994) EMBO J. 13, 534-542. Suzuki, T. et al. (1994) EMBO J. 13, 1114-1122 Ando, K. et al. (1999) J. Neurosci. 19, 4421-4427. Iijima, K.I. et al. (2000) J. Neurochem. 75, 1085-1091

Conjugate

Unconjugated

Storage Buffer

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form

liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Modification

Phospho-Thr668

Additional information

Size

100?l

Certificate of Analysis