L1 Antibody

Aliases L1 Antibody Type Polyclonal Antibody Species Human papillomavirus type 18 Uniprot ID P06794 Immunogen Recombinant HPV18 Major capsid protein L1 protein (358-533AA) Raised In Rabbit Species Reactivity Human papillomavirus type 18 Tested Applications ELISA, WB;Not yet tested in other applications. Background / Function Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on the basement membrane to provide initial virion attachment to target cells. Basement membrane is exposed only after epithelium trauma. Additionally, the alpha6 integrin complexed with either beta1 or beta4 integrin has been proposed to act as a coreceptor recognized by L1. Once attached, integrin complexed with beta4 integrin has been proposed to act as a coreceptor recognized by L1. Once attached, the virion enters the host cell via clathrin-mediated endocytosis and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2. Isotype IgG Conjugate Unconjugated Storage Buffer Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form Liquid Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze. Purity Caprylic Acid Ammonium Sulfate Precipitation purified Modification HPV18 Major capsid protein L1 protein Research Others Literature [1] "Human papillomavirus type 16 DNA sequence."Seedorf K., Krammer G., Durst M., Suhai S., Rowekamp W.G.Virology 145:181-185(1985) [2] "Nucleotide sequences and further characterization of human papillomavirus DNA present in the CaSki, Si